Electron Tomography Reveals the Steps in Filovirus Budding

Abstract

The filoviruses, Marburg and Ebola, are non-segmented negative-strand RNA viruses causing severe hemorrhagic fever with high mortality rates in humans and nonhuman primates. The sequence of events that leads to release of filovirus particles from cells is poorly understood. Two contrasting mechanisms have been proposed, one proceeding via a "submarine-like… (More)
DOI: 10.1371/journal.ppat.1000875

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