Urea, 10% in cream or ointment, appl ied in vivo for 24 and 48 hours with part occl usion changes the inner structure of the horny cells, depending on time and the excipients. Splitting of the keratin changes the matrix and the osmiophilic behaviour, especia lly in the upper regions. After 48 hours fine granulation within the horny cel ls and enhancement of… (More)
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