Electron Micrography of the Virus of Influenza

@article{Mosley1946ElectronMO,
  title={Electron Micrography of the Virus of Influenza},
  author={V. M. Mosley and Ralph Walter Graystone Wyckoff},
  journal={Nature},
  year={1946},
  volume={157},
  pages={263-263}
}
THE recognized elementary bodies of influenza are spherical with diameters1 of 80–100 millimicrons. These spheres are clearly evident in shadowed electron micrographs2, but such photographs also indicate the presence of elongated forms that have the diameter of the spheres and frequently appear partly segmented into them. 
The structure of influenza virus filaments and spheres.
TLDR
Influenza virus filaments treated with acid on an electron microscope film developed along their length rows of spheres which were completely digested by trypsin, and by their behaviour with enzymes have been identified as ribonucleoprotein. Expand
The staining of influenza virus filaments.
  • J. Lindenmann
  • Biology, Medicine
  • Journal of general microbiology
  • 1957
SUMMARY: Influenza virus filaments can be made visible in the ordinary microscope by various staining procedures; a technique involving potassium permanganate and Victoria blue is described.
The genetics of virus particle shape in equine influenza A virus
Many human strains of influenza A virus produce highly pleomorphic virus particles that at the extremes can be approximated as either spheres of around 100 nm diameter or filaments of similarExpand
Some properties of influenza virus filaments shown by electron microscopic particle counts.
TLDR
A strain of influenza virus A which produced abundant filaments was more efficient in agglutinating red cells than non-filamentous strains, and was shown by filtration experiments to be due to the filaments. Expand
Studies on filamentary forms of influenza virus with special reference to the use of dark-ground-microscopy
TLDR
Donald and Isaacs (1954) used quantitative methods to approach the problem of whether filaments were or were not infective, and provided cogent evidence that filaments represented a form of the virus. Expand
Influenzal encephalitis in mice
TLDR
Limitation of the infective site to one pole of the virion accords with data in the literature relating to absence of change in infectivity after sonication. Expand
An immunofluorescence study of influenza virus filament formation
TLDR
The immunofluorescence technique was quicker than thin section electron microscope and was a more sensitive procedure for the detection of filamentous forms of influenza virus than electron microscopy using negative stain, which enabled the antigenic composition of the filaments to be observed. Expand
The multiplication of influenza viruses in the fertile egg: A Report to the Medical Research Council.
  • L. Hoyle
  • Biology, Medicine
  • The Journal of hygiene
  • 1950
Hoyle & Fairbrother (1937) showed that tissues infected with influenza virus contained two distinct particles, the infective virus elementary body, and a smaller particle, the soluble antigen, whichExpand
STUDIES OF TWO KINDS OF VIRUS PARTICLES WHICH COMPRISE INFLUENZA A2 VIRUS STRAINS
TLDR
Seven strains of influenza A2 virus were serially passed in the chick embryo, and morphological characteristics of the passages were examined in the electron microscope, and both highly filamentous and spherical populations of "+" and of "-" virus particles were obtained. Expand
ARTIFACTS, WITH OTHER NONSPECIFIC APPEARANCES RESEMBLING VIRUS PARTICLES, AND THE SO-CALLED FILAMENTOUS FORMS OF INFLUENZA AND FOWL PEST VIRUSES IN HUMAN SKIN TISSUE FLUID EXAMINED WITH THE ELECTRON MICROSCOPE
In an electron microscope study of Treponema carateum in human tissue fluid from pinta skin lesions, filaments were seen that were either similar or identical to the filamentous forms of influenzaExpand
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References

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Electron Shadow-Micrography of Virus Particles.*
Summary A new procedure is described for the electron microscopy of small objects. This technique, illustrated by photographs of purified influenza and tobacco mosaic viruses, involves the obliqueExpand