Electron Crystal Structure of the Transcription Factor and DNA Repair Complex, Core TFIIH


Core TFIIH from yeast, made up of five subunits required both for RNA polymerase II transcription and nucleotide excision DNA repair, formed 2D crystals on charged lipid layers. Diffraction from electron micrographs of the crystals in negative stain extended to about 13 angstrom resolution, and 3D reconstruction revealed several discrete densities whose… (More)
DOI: 10.1016/S0092-8674(00)00083-0


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