Electromyography in relation to end-plate acetylcholinesterase in rats poisoned by different organophosphates.

@article{Bleecker1994ElectromyographyIR,
  title={Electromyography in relation to end-plate acetylcholinesterase in rats poisoned by different organophosphates.},
  author={Jan L. De Bleecker and Koen Van Den Abeele and Jacques L De Reuck},
  journal={Neurotoxicology},
  year={1994},
  volume={15 2},
  pages={331-40}
}
Organophosphate (OP) poisoning produces various forms of acute, subacute, or delayed neurotoxicity. We investigated in vivo the relationship between clinical, histochemical and electromyographic (EMG) parameters in rats at various stages of poisoning by paraoxon or fenthion. Paraoxon is acutely toxic, whereas fenthion produces more sustained AChE inhibition. Fenthion has been involved in a subacute type of OP-related neurotoxicity in patients, the so-called intermediate syndrome. The animals… CONTINUE READING