Electromotive administration of a new morphine formulation: morphine citrate.

Abstract

Two formulations of morphine citrate were synthesized: trimorphine citrate, 3(MH)+(C6H5O7)3- and morphine sodium citrate, 3(MH)+3Na+2(C6H5O7)3-. Four healthy individuals volunteered to undergo electromotive administration of the two formulations. Application of electric current (2 mA) to solutions of trimorphine citrate for 1 h resulted in iontophoretic… (More)

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@article{Stephen1994ElectromotiveAO, title={Electromotive administration of a new morphine formulation: morphine citrate.}, author={R. John Stephen and Davide Miotti and Raffaella Bettaglio and C. Rossi and Cesare Bonezzi}, journal={Artificial organs}, year={1994}, volume={18 6}, pages={461-5} }