Electromechanical effects of okadaic acid isolated from black sponge in guinea-pig ventricular muscles.

@article{Kodama1986ElectromechanicalEO,
  title={Electromechanical effects of okadaic acid isolated from black sponge in guinea-pig ventricular muscles.},
  author={Itsuo Kodama and Naomi Kondo and Shoji Shibata},
  journal={The Journal of physiology},
  year={1986},
  volume={378},
  pages={359-73}
}
Okadaic acid is a monocarboxylic acid with a unique molecular structure of C44H66O13. Okadaic acid, at concentrations above 10(-5) M, caused a dose-dependent increase of contractile force in guinea-pig isolated ventricular muscles. The increase of contractile force by okadaic acid (1-4 X 10(-5) M) was accompanied by a prolongation of action potential duration (a.p.d.), while a.p.d. was shortened by okadaic acid at above 10(-4) M. The okadaic-acid-induced changes in contractile force and a.p.d… CONTINUE READING

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