Electromechanical action of dofetilide and D-sotalol during simulated metabolic acidosis in isolated guinea pig ventricular muscle.

@article{Yang1992ElectromechanicalAO,
  title={Electromechanical action of dofetilide and D-sotalol during simulated metabolic acidosis in isolated guinea pig ventricular muscle.},
  author={Tao Yang and P{\aa}l M. Tande and Helge Refsum},
  journal={Journal of cardiovascular pharmacology},
  year={1992},
  volume={20 6},
  pages={889-94}
}
We examined the electromechanical effects of two class III antiarrhythmic agents, dofetilide (UK-68,798) and D-sotalol, in acidic myocardium. Right ventricular papillary muscle preparations isolated from guinea pigs were divided into three groups (n = 6 per group): (a) drug-free, (b) dofetilide (10 nM), and (c) D-sotalol (30 microM). At normal extracellular… CONTINUE READING