Electrolyte-induced compositional heterogeneity: a novel approach for rate-controlled oral drug delivery.

@article{Pillay1999ElectrolyteinducedCH,
  title={Electrolyte-induced compositional heterogeneity: a novel approach for rate-controlled oral drug delivery.},
  author={Viness Pillay and Reza Fassihi},
  journal={Journal of pharmaceutical sciences},
  year={1999},
  volume={88 11},
  pages={1140-8}
}
In this work a new approach for in situ interactions between drug and electrolyte(s) is devised to control the release of highly water soluble drugs from oral hydrophilic monolithic systems. The model drug diltiazem hydrochloride (water solubility in excess of 50% at 25 degrees C), in conjunction with specific electrolytes, was principally employed in the design of swellable tablet formulations comprised of hydrophilic polymers such as hydroxypropylmethlcellulose (HPMC) or poly(ethylene oxide… CONTINUE READING