Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1.

@article{Balasubramaniam2003ElectrogramPA,
  title={Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1.},
  author={Richard Balasubramaniam and Andrew A. Grace and R. C. Saumarez and Jamie I. Vandenberg and Christopher L-H Huang},
  journal={The Journal of physiology},
  year={2003},
  volume={552 Pt 2},
  pages={
          535-46
        }
}
Mutations in KCNE1, the gene encoding the beta subunit of the slowly activating delayed rectifier potassium current (IKs) channel protein, may lead to the long QT syndrome (LQTS), a condition associated with enhanced arrhythmogenesis. Mice with homozygous deletion of the coding sequence of KCNE1 have inner ear defects strikingly similar to those seen in the corresponding human condition. The present study demonstrated and assessed the mechanism of ventricular arrhythmias in Langendorff-perfused… CONTINUE READING
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