Electrogenic sodium absorption and chloride secretion by an inner medullary collecting duct cell line (mIMCD-K2).

@article{Kizer1995ElectrogenicSA,
  title={Electrogenic sodium absorption and chloride secretion by an inner medullary collecting duct cell line (mIMCD-K2).},
  author={N L Kizer and Brandon Lewis and Bruce A. Stanton},
  journal={The American journal of physiology},
  year={1995},
  volume={268 2 Pt 2},
  pages={F347-55}
}
The initial segment of the inner medullary collecting duct (IMCDi) absorbs Na+ by an electrogenic mechanism and plays an important role in regulating the composition and volume of the urine. The purpose of the present study was to establish a permanent cell line derived from the IMCDi, which has the ion transport properties of the IMCDi in vivo. To this end, we isolated IMCD cells from the IMCDi of a mouse, Tg(SV40E) Bri 7, transgenic for the early region of SV40 (large T antigen) and… CONTINUE READING

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