Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics.

Abstract

AIMS This study was designed to evaluate the changes in EEG power spectra and EEG coherence in a ketamine model of psychosis in rats. Analyses of behavioral measurements--locomotion and sensorimotor gating--and the pharmacokinetics of ketamine and norketamine were also conducted. METHODS Ketamine and norketamine levels in rat sera and brains were analyzed… (More)
DOI: 10.1159/000321803

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@article{Plenek2011ElectroencephalographicSA, title={Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics.}, author={Tom{\'a}{\vs} P{\'a}len{\'i}{\vc}ek and Michaela Fuj{\'a}kov{\'a} and Martin Brunovsk{\'y} and Marie Anna Balikova and Jiř{\'i} Hor{\'a}{\vc}ek and Ingmar Gorman and Filip Tyl{\vs} and Barbora Ti{\vs}lerov{\'a} and Peter {\vS}{\'o}{\vs} and Věra Buben{\'i}kov{\'a}-Vale{\vs}ov{\'a} and Cyril H{\"{o}schl and Vladimir Krajca}, journal={Neuropsychobiology}, year={2011}, volume={63 4}, pages={202-18} }