Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies

  title={Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies},
  author={A. V. Wieringen and C. Binnie and P. D. Boer and W. Boas and J. D. Vries},
  journal={Epilepsy Research},
  • A. V. Wieringen, C. Binnie, +2 authors J. D. Vries
  • Published 1987
  • Psychology, Medicine
  • Epilepsy Research
  • A recent survey has shown that the EEG is of doubtful value as an outcome variable in clinical antiepileptic drug (AED) trials. Analysis of findings in 6 trials shows that in only two no consistent effect was seen; that in two power spectral analysis provided additional information to confirm changes in background activity; that in one a close relationship could be established between reduction in frequency of epileptiform discharges and administration of the trial drug (lamotrigine), and that… CONTINUE READING
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