Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness.

  title={Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness.},
  author={Dinesh Pal and Viviane S. Hambrecht-Wiedbusch and Brian Henry Silverstein and George A. Mashour},
  journal={British journal of anaesthesia},
  volume={114 6},
BACKGROUND There is limited understanding of cortical neurochemistry and cortical connectivity during ketamine anaesthesia. We conducted a systematic study to investigate the effects of ketamine on cortical acetylcholine (ACh) and electroencephalographic coherence. METHODS Male Sprague-Dawley rats (n=11) were implanted with electrodes to record electroencephalogram (EEG) from frontal, parietal, and occipital cortices, and with a microdialysis guide cannula for simultaneous measurement of ACh… CONTINUE READING
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