Electroencephalographic Investigations During Evaluation of the Antiepileptic Agent Sulthiame*

  title={Electroencephalographic Investigations During Evaluation of the Antiepileptic Agent Sulthiame*},
  author={Robert J. Wilkus and John R. Green},
In a double‐blind crossover trial of sulthiame, a carbonic anhydrase inhibitor, and diphenylhydantoin as sole medication for partial epileptic seizures, EEG changes were related to the drug administered. On sulthiame, the parieto‐occipital rhythms in awake patients were faster and the response to hyperventilation was less pronounced than when the patients were treated with diphenylhydantoin. Epileptiform activity tended to be more frequent on sulthiame and was consistent with change in… 

Sulthiame: Evaluation as an Anticonvulsant

Although the few patients benefited by sulthiame alone felt more alert, neuropsychologic tests showed that organic communications and intellectual processing deficits were accentuated and Hyperpnea could be troublesome.

Effects of the Removal of Phenytoin, Carbamazepine, and Valproate on the Electroencephalogram

Subsequent EEGs, during and at the end of drug reduction, showed an increase in bursts of interictal epileptiform activity (IEA) and in slow activity in patients whoHad a marked increase in seizures on discontinuation of an an‐tiepileptic drug had a slower mean dominant rhythm at baseline than did patients who did not have an increased in seizures.

Effects of Sulthiame Upon Intellectual, Neuropsychological, and Social Functioning Abilities Among Adult Epileptics: Comparison with Diphenylhydantoin

The results showed significantly less impairment with treatment by diphenylhydan‐toin than by sulthiame, and substantial differences were revealed on intellectual tasks, on tasks calling for sustained concentration and attention, and on psychomotor problem‐solving tasks.

Effects of antiepileptic drugs on interictal epileptiform discharges in focal epilepsies: an update on current evidence

This review updates the existing literature on the effects of classical and newer AEDs on focal IEDs, emphasizing the scarcity of data concerning the former and the potential limits of available clinical and experimental data.


  • Biology
  • 1991
Experimental studies have indicated that neurotransmitters may play an important role in the physiopathology of epilepsy, and the existence of hypometabolic zones in the interictal state and hypermetabolism during spontaneous or provoked seizures is revealed.

Efficacy of Standard Anticonvulsants in Monkey Model with Spontaneous Motor Seizures

In most monkeys the frequency and severity of seizures were correlated to the number of interictal spikes in the EEG, and were inversely related to the level of drug in plasma, and the effects of diphenylhydan‐toin (DPH), phenobarbital, and primidone on spontaneous seizures were evaluated for 8 months.

Neuropsychological Correlates of the Electroencephalogram in Epileptics

It is suggested that EEG epileptiform discharges serve as an index of brain function having a bearing upon neuropsychological performance of epileptics.

Relationships between intelligence and electroencephalographic epileptiform activity in adult epileptics

Lower intelligence levels were associated with the presence of discharges, especially when they were generalized rather than focal and when they occurred at an average rate of more than one per minute.



Sulthiame: Evaluation as an Anticonvulsant

Although the few patients benefited by sulthiame alone felt more alert, neuropsychologic tests showed that organic communications and intellectual processing deficits were accentuated and Hyperpnea could be troublesome.

Clinical evaluation of a new anticonvulsant, sulthiame

If drowsiness and ataxia are as uncommon in patients receiving sulthiame as reported, this agent may be a valuable anticonvulsant drug of particular benefit to mentally retarded epileptic patients.

Clinical Experience with Sulthiame (Ospolot)

  • M. C. Liu
  • Psychology, Medicine
    British Journal of Psychiatry
  • 1966
The anticonvulsants now in general use have made epilepsy among the mentally subnormal no longer the problem it was. However, the treatment of long standing epilepsy associated with behaviour

Clinical and Electroencephalographic Correlations with Serum Levels of Diphenylhydantoin

The correlation is described between the serum level of diphenylhydantoin and the anticonvulsant effect of the drug, the incidence of paroxysmal abnormalities in the electroencephalogram, and the occurrence of toxic side-effects.

Dilantin toxicity

Dilantin alone or in combination with other drugs has been the sheet anchor in the management of epileptics, and with judicious use it may be said that it alone is responsible for the prevention of more seizures than any other drug.

Changes in repeat electroencephalograms in epileptics

This article is concerned primarily with electroencephalographic observations and the pathophysiologic significance of changes occurring under various circumstances-not with treatment or prognosis of convulsive disorders.

The Use of Ospolot in Temporal Lobe Epilepsy A Preliminary Communication

  • V. Smyth
  • Psychology, Medicine
  • 1964
Out‐patients with frequent, poorly controlled, attacks of temporal lobe epilepsy were treated with Ospolot, either alone or in combination with other anticonvulsant drugs, and the number of attacks was reduced.

Factors Related to the Occurrence of Typical Paroxysmal Abnormalities in the EEG Records of Epileptic Patients

The results of the present analysis would not seem to support the common assumption that records obtained while the patient is on medication are less likely to be positive, and instead suggest that the closer the examination to a seizure and/or the higher the seizure frequency, the greater the probability that a record would be positive.