Electroencephalographic Investigations During Evaluation of the Antiepileptic Agent Sulthiame*

@article{Wilkus1974ElectroencephalographicID,
  title={Electroencephalographic Investigations During Evaluation of the Antiepileptic Agent Sulthiame*},
  author={Robert J. Wilkus and John R. Green},
  journal={Epilepsia},
  year={1974},
  volume={15}
}
In a double‐blind crossover trial of sulthiame, a carbonic anhydrase inhibitor, and diphenylhydantoin as sole medication for partial epileptic seizures, EEG changes were related to the drug administered. On sulthiame, the parieto‐occipital rhythms in awake patients were faster and the response to hyperventilation was less pronounced than when the patients were treated with diphenylhydantoin. Epileptiform activity tended to be more frequent on sulthiame and was consistent with change in… 
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22 Citations
Background Citations
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Results Citations
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22 Citations

Sulthiame: Evaluation as an Anticonvulsant

Although the few patients benefited by sulthiame alone felt more alert, neuropsychologic tests showed that organic communications and intellectual processing deficits were accentuated and Hyperpnea could be troublesome.

Effects of the Removal of Phenytoin, Carbamazepine, and Valproate on the Electroencephalogram

Subsequent EEGs, during and at the end of drug reduction, showed an increase in bursts of interictal epileptiform activity (IEA) and in slow activity in patients whoHad a marked increase in seizures on discontinuation of an an‐tiepileptic drug had a slower mean dominant rhythm at baseline than did patients who did not have an increased in seizures.

Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies

Effects of Sulthiame Upon Intellectual, Neuropsychological, and Social Functioning Abilities Among Adult Epileptics: Comparison with Diphenylhydantoin

The results showed significantly less impairment with treatment by diphenylhydan‐toin than by sulthiame, and substantial differences were revealed on intellectual tasks, on tasks calling for sustained concentration and attention, and on psychomotor problem‐solving tasks.

Effects of antiepileptic drugs on interictal epileptiform discharges in focal epilepsies: an update on current evidence

This review updates the existing literature on the effects of classical and newer AEDs on focal IEDs, emphasizing the scarcity of data concerning the former and the potential limits of available clinical and experimental data.

DRUG MONITORING IN CLINICAL TRIALS OF NEW ANTIEPILEPTIC DRUGS

  • Biology
  • 1991
Experimental studies have indicated that neurotransmitters may play an important role in the physiopathology of epilepsy, and the existence of hypometabolic zones in the interictal state and hypermetabolism during spontaneous or provoked seizures is revealed.

Efficacy of Standard Anticonvulsants in Monkey Model with Spontaneous Motor Seizures

In most monkeys the frequency and severity of seizures were correlated to the number of interictal spikes in the EEG, and were inversely related to the level of drug in plasma, and the effects of diphenylhydan‐toin (DPH), phenobarbital, and primidone on spontaneous seizures were evaluated for 8 months.

Changes of interictal epileptiform discharges during medication withdrawal and seizures: A scalp EEG marker of epileptogenicity

Neuropsychological Correlates of the Electroencephalogram in Epileptics

It is suggested that EEG epileptiform discharges serve as an index of brain function having a bearing upon neuropsychological performance of epileptics.

Relationships between intelligence and electroencephalographic epileptiform activity in adult epileptics

Lower intelligence levels were associated with the presence of discharges, especially when they were generalized rather than focal and when they occurred at an average rate of more than one per minute.

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