Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep

@article{Huupponen2008ElectroencephalogramSA,
  title={Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep},
  author={Eero Huupponen and Anu T. Maksimow and Petteri Lapinlampi and Mika O. K. S{\"a}rkel{\"a} and Antti Saastamoinen and Amir Snapir and Harry Scheinin and Mika Scheinin and Pekka Meril{\"a}inen and Sari-Leena Himanen and Satu K. J{\"a}{\"a}skel{\"a}inen},
  journal={Acta Anaesthesiologica Scandinavica},
  year={2008},
  volume={52}
}
Background: Dexmedetomidine, a selective α2‐adrenoceptor agonist, induces a unique, sleep‐like state of sedation. The objective of the present work was to study human electroencephalogram (EEG) sleep spindles during dexmedetomidine sedation and compare them with spindles during normal physiological sleep, to test the hypothesis that dexmedetomidine exerts its effects via normal sleep‐promoting pathways. 
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The effectiveness and safety of IN dexmedetomidine for sedation of patients undergoing electroencephalogram (EEG) and auditory brain response (ABR) testing are examined.
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TLDR
The differences between anesthesia- and sleep-induced altered states from the perspective of neural oscillations are discussed, including the three stages of non-rapid eye movement sleep.
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TLDR
This study compares the sedative efficacy and EEG effects of dexmedetomidine and midazolam.
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TLDR
How two different classes of sedatives can selectively interact with some nodal points of the circuitry that promote wakefulness allowing the transition to NREM sleep is reviewed to aid the design of more precise acting sedatives, and reveal more about the natural sleep-wake circuitry.
Sedation for Electroencephalography With Dexmedetomidine or Chloral Hydrate: A Comparative Study on the Qualitative and Quantitative Electroencephalogram Pattern
TLDR
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Effects of dexmedetomidine sedation on the EEG in children
Objectives:  To examine the effects of dexmedetomidine sedation on EEG background and epileptiform activity in children, comparing it to natural sleep.
Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.
TLDR
In the Sprague Dawley rat, dexmedetomidine-induced sedation is characterized by behavioral, electrographic, and immunohistochemical phenotypes that are distinctly different from similar measures obtained during sleep.
Dexmedetomidine for EEG sedation in children with behavioral disorders
To evaluate the efficacy and safety of sedation with dexmedetomidine, a highly selective α2‐agonist with sedative effect, for EEG recording in children with behavioral disorders.
Changes in brain activation during sedation induced by dexmedetomidine
TLDR
Cerebral cortical activity was significantly altered in various brain areas during DEX sedation, including parts of the default mode network and common midline core in different frequency ranges, which may elucidate the mechanisms underlying DEx sedation.
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