Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug-resistant depression

@article{Zhang2009ElectroconvulsiveTI,
  title={Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug-resistant depression},
  author={Xiaobin Zhang and Zhijun Zhang and Wei-wei Sha and Chunming Xie and Guangjun Xi and Hong-hui Zhou and Yumei Zhang},
  journal={Psychiatry Research},
  year={2009},
  volume={170},
  pages={273-275}
}

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References

SHOWING 1-10 OF 32 REFERENCES
Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression.
TLDR
This is the first report of an increase in plasma BDNF concentration in patients receiving ECT, and preliminary results encourage further investigation of a neurotrophic mechanism for the antidepressant effect of ECT.
Effect of treatment on serum glial cell line-derived neurotrophic factor in depressed patients
Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders.
TLDR
It is suggested that lower GDNF levels might be involved in the pathophysiology of mood disorders, although this preliminary study has several limitations.
Altered expression of neurotrophic factors in patients with major depression.
Molecular and Cellular Actions of Chronic Electroconvulsive Seizures
TLDR
The hypothesis that ECS and antidepressant drugs, via regulation of neurotrophic factors, reverse the atrophy of stress-vulnerable neurons or protect these neurons from further damage is led to.
Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells.
TLDR
This study suggests that stimulation of GDNF release from glial cells by antipsychotic drugs might underlie some of their neuroprotective properties in situ.
...
...