Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression.

  title={Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression.},
  author={Thea Pinholt Lillethorup and Peter Iversen and Jesper Fontain and Gregers Wegener and Doris J. Doudet and Anne M. Landau},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  volume={25 3},
Despite years of drug development, electroconvulsive therapy (ECT) remains the most effective treatment for severe depression. The exact therapeutic mechanism of action of ECT is still unresolved and therefore we tested the hypothesis that the beneficial effect of ECT could in part be the result of increased noradrenergic neurotransmission leading to a decrease in α2-adrenoceptor binding. We have previously shown that both the Flinders sensitive line (FSL) and Flinders resistant line (FRL) rats… CONTINUE READING
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The Rat Brain in Stereotaxic Coordinates, fourth ed

  • G. Paxinos, C. Watson
  • 1998
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