Electroconvulsive shock and lidocaine reveal rapid consolidation of spatial working memory in the water maze.

@article{Bohbot1996ElectroconvulsiveSA,
  title={Electroconvulsive shock and lidocaine reveal rapid consolidation of spatial working memory in the water maze.},
  author={V Bohbot and Pavel Ot{\'a}hal and Zhijie Liu and L. Nadel and Jan Bure{\vs}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 9},
  pages={4016-9}
}
Head trauma leading to concussion and electroconvulsive shock (ECS) in humans causes amnesia for events that occurred shortly before the injury (retrograde amnesia). The present experiment investigated the amnesic effect of lidocaine and ECS in 25 rats trained on a working memory version of the Morris water task. Each day, the escape platform was moved to a new location; learning was evidenced by a decrease in the latency to find the platform from the first to the second trial. "Consolidation… CONTINUE READING

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