Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus.

@article{Segawa2013ElectroconvulsiveSB,
  title={Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus.},
  author={Masahiro Segawa and Shigeru Morinobu and Tomoya Matsumoto and Manabu Fuchikami and Shigeto Yamawaki},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 2},
  pages={339-50}
}
Electroconvulsive therapy is the most effective treatment for antidepressant-resistant depression, although its mechanism has not been fully elucidated. Previous studies have demonstrated that electroconvulsive seizures (ECS) induce expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, in contrast with mature BDNF (mBDNF) known to have antidepressant effects, its precursor (pro-BDNF) has harmful effects on neurons. We therefore hypothesized that efficient… CONTINUE READING
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