Electrochemotherapy with Calcium Chloride and 17β-Estradiol Modulated Viability and Apoptosis Pathway in Human Ovarian Cancer

  title={Electrochemotherapy with Calcium Chloride and 17$\beta$-Estradiol Modulated Viability and Apoptosis Pathway in Human Ovarian Cancer},
  author={Zofia Łapińska and Michał Dębiński and Anna Szewczyk and Anna Choromańska and Julita Kulbacka and Jolanta Saczko},
Estrogens (Es) play a significant role in the carcinogenesis and progression of ovarian malignancies. Depending on the concentration, Es may have a protective or toxic effect on cells. Moreover, they can directly or indirectly affect the activity of membrane ion channels. In the presented study, we investigated in vitro the effectiveness of the ovarian cancer cells (MDAH-2774) pre-incubation with 17β-estradiol (E2; 10 µM) in the conventional chemotherapy (CT) and electrochemotherapy (ECT) with… 

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