Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach

@article{Testori2010ElectrochemotherapyFC,
  title={Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach},
  author={Alessandro A. E. Testori and Giulio Tosti and Chiara Martinoli and Giuseppe Spadola and Francesco Cataldo and Francesco Verrecchia and Federica Baldini and Massimo Mosconi and Javier Soteldo and Ines Tedeschi and Claudia Passoni and Chiara Pari and Alessandra di Pietro and Pier Francesco Ferrucci},
  journal={Dermatologic Therapy},
  year={2010},
  volume={23}
}
Electroporation uses pulsed, high‐intensity electric fields to temporarily increase cell membrane permeability by creation of pores, through which small molecules, such as chemotherapeutic agents, can diffuse inside cells before they reseal. The combination of electroporation with the administration of otherwise low‐permeant cytotoxic drugs is known as electrochemotherapy (ECT). The two most commonly used drugs are bleomycin and cisplatin. ECT has already been proven to be effective in diverse… Expand
Locally enhanced chemotherapy by electroporation: clinical experiences and perspective of use of electrochemotherapy.
TLDR
Considering the proven safety in several different clinical applications electroporation should be viewed as a clinical platform technology with wide perspectives for use in ECT, gene therapy and DNA vaccination. Expand
Utility of electrochemotherapy in melanoma treatment
TLDR
Treatment regimens combining ECT to biological response modifiers (interleukin-2, interferon and immunotherapeutic compounds) and immunotherapy combined to ECT could broaden the therapeutic indications of ECT, by rendering it effective also on distant unreachable or untreated lesions. Expand
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TLDR
In Slovenia the authors are at the forefront in the treatment of liver tumors and head and neck tumors, while the others are developing electrochemotherapy for treatment of bone and brain metastases as well as endoluminal tumors. Expand
Electrochemotherapy of Breast Cancer
TLDR
Small tumor size, hormone receptor positivity, low proliferative index, and absence of visceral metastases were predictors of response to treatment, and electrochemotherapy represents a promising treatment modality for patients with locoregional recurrence from breast cancer and for metastatic patients with symptomatic skin tumor involvement. Expand
Electrochemotherapy as a New Modality in Interventional Oncology: A Review
TLDR
Recent published clinical experiences of electrochemotherapy use in deep-seated tumors with particular focus on liver cases are reviewed, with a short insight in the treatment of bone metastases, unresectable pancreas cancer, and soft tissue sarcoma. Expand
Electrochemotherapy: An enhancement of cytotoxicity of anticancer drugs
A proportion of patients who have undergone extensive tumor treatment, including all conventional treatment modalities, face the problem of metastases. Progression of the disease in cutaneous tissue,Expand
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TLDR
Recent technological advances in electrochemotherapy are described, which allow treatment of liver and bone metastases, soft tissue sarcomas, brain tumors, and colorectal and esophageal tumors. Expand
Electrochemotherapy in Breast Cancer: A Review of References.
TLDR
The repeated use of electrochemotherapy has allowed for an increase in the rate of complete remissions and the favourable cost-benefit ratio makes this method of treatment very interesting in clinical practice and, as a result, it is already being used successfully in many German hospitals. Expand
The use of cisplatin electrochemotherapy in nonmelanoma skin cancers: A single‐center study
TLDR
This study clearly show that ECT with intralesional cisplatin ECT is a valuable and safety procedure for nonmelanoma skin cancer and cutaneous tumor metastasis. Expand
Electrochemotherapy in the treatment of melanoma skin metastases: a report on 31 cases.
TLDR
Electrochemotherapy is a very effective, safe, and efficient treatment for advanced locoregional disease in patients with unresectable melanoma lesions. Expand
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References

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Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors
TLDR
The biological basis of electroporation therapy is outlined in this review and basic science studies and the limited clinical studies that have involved electrochemotherapy are reviewed, placed on trials involving melanoma, head and neck cancers and other primary and metastatic skin cancers. Expand
Successful treatment of metastatic skin lesions with electrochemotherapy.
TLDR
The first use of electrochemotherapy in cutaneous metastases of transitional cell carcinoma is reported, and it is reported that the drug bleomycin is administered in nontoxic doses locally efficient. Expand
Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation.
TLDR
Eleven studies of electrochemotherapy of malignant cutaneous or subcutaneous lesions, e.g., metastases from melanoma, breast or head- and neck cancer, are reviewed, finding the treatment was well tolerated and could be performed on an out-patient basis. Expand
Bases and rationale of the electrochemotherapy
TLDR
Electrochemotherapy is a non-thermal tumour ablation modality, safe and effective on any type of solid tumour, and its efficacy is very high on the treated nodules, whatever the tumour histological origin. Expand
Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma
TLDR
Electrochemotherapy is an effective treatment in the palliative management of unresectable recurrent disease with overall objective response rates of approximately 80–90%. Expand
Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy
TLDR
A clinical study was initiated to determine if this mode of treatment would be effective against certain primary and metastatic cutaneous malignancies. Expand
Electrochemotherapy: advantages and drawbacks in treatment of cancer patients
TLDR
Enhanced drug delivery can substantially potentiate chemotherapeutic drug effectiveness, locally at the site of the cell electroporation by electric pulses, without affecting drug effectiveness in the tissues that were not exposed to electric pulses. Expand
Bleomycin-mediated electrochemotherapy of basal cell carcinoma.
TLDR
This is the first study that documents the effects of bleomycin-mediated electrochemotherapy on BCC, and studies are ongoing to see whether additional antitumour effects can be produced in patients with BCC by this route of administration. Expand
Bleomycin-mediated electrochemotherapy of metastatic melanoma.
TLDR
This is the first study that documents the antitumor effects of ECT in metastatic melanoma, and may be an effective alternative to palliative surgery or irradiation in these patients. Expand
Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy.
TLDR
ECT was shown to be an effective local treatment and was effective regardless of the histological type of the tumour, and offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate. Expand
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