Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach

@article{Testori2010ElectrochemotherapyFC,
  title={Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach},
  author={Alessandro A. E. Testori and Giulio Tosti and Chiara Martinoli and Giuseppe Spadola and Francesco Cataldo and Francesco Verrecchia and Federica Baldini and Massimo Mosconi and Javier Soteldo and Ines Tedeschi and Claudia Passoni and Chiara Pari and Alessandra di Pietro and Pier Francesco Ferrucci},
  journal={Dermatologic Therapy},
  year={2010},
  volume={23}
}
Electroporation uses pulsed, high‐intensity electric fields to temporarily increase cell membrane permeability by creation of pores, through which small molecules, such as chemotherapeutic agents, can diffuse inside cells before they reseal. The combination of electroporation with the administration of otherwise low‐permeant cytotoxic drugs is known as electrochemotherapy (ECT). The two most commonly used drugs are bleomycin and cisplatin. ECT has already been proven to be effective in diverse… 

Utility of electrochemotherapy in melanoma treatment

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Treatment regimens combining ECT to biological response modifiers (interleukin-2, interferon and immunotherapeutic compounds) and immunotherapy combined to ECT could broaden the therapeutic indications of ECT, by rendering it effective also on distant unreachable or untreated lesions.

Electrochemotherapy -an effective method for the treatment of tumors with a combination of chemotherapeutic agent and electric field

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In Slovenia the authors are at the forefront in the treatment of liver tumors and head and neck tumors, while the others are developing electrochemotherapy for treatment of bone and brain metastases as well as endoluminal tumors.

Electrochemotherapy of Breast Cancer

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Small tumor size, hormone receptor positivity, low proliferative index, and absence of visceral metastases were predictors of response to treatment, and electrochemotherapy represents a promising treatment modality for patients with locoregional recurrence from breast cancer and for metastatic patients with symptomatic skin tumor involvement.

Electrochemotherapy: An enhancement of cytotoxicity of anticancer drugs

TLDR
ECT, in general, can be considered as a palliative option for cancers for which standard treatments have failed or proved to be insufficient and new technological developments are needed that will enable treatment of these tumors in daily clinical practice.

Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors

TLDR
Recent technological advances in electrochemotherapy are described, which allow treatment of liver and bone metastases, soft tissue sarcomas, brain tumors, and colorectal and esophageal tumors.

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors

TLDR
The preclinical and clinical use of ECT on drug-resistant solid tumors, such as head and neck squamous cell carcinoma, breast cancer, gynecological cancer and, finally, colorectal cancer are described.

Electrochemotherapy in Breast Cancer: A Review of References.

TLDR
The repeated use of electrochemotherapy has allowed for an increase in the rate of complete remissions and the favourable cost-benefit ratio makes this method of treatment very interesting in clinical practice and, as a result, it is already being used successfully in many German hospitals.

The use of cisplatin electrochemotherapy in nonmelanoma skin cancers: A single‐center study

TLDR
This study clearly show that ECT with intralesional cisplatin ECT is a valuable and safety procedure for nonmelanoma skin cancer and cutaneous tumor metastasis.

Electrochemotherapy in the treatment of melanoma skin metastases: a report on 31 cases.

Electrochemotherapy: A New Arm against Cancer

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Electrochemotherapy is a therapy with antitumor effect, in which there is a combination of administration of chemotherapeutic drugs intravenously, or intratumorally and tumor application of short and high-intensity electric pulses.
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References

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TLDR
The biological basis of electroporation therapy is outlined in this review and basic science studies and the limited clinical studies that have involved electrochemotherapy are reviewed, placed on trials involving melanoma, head and neck cancers and other primary and metastatic skin cancers.

Bases and rationale of the electrochemotherapy

Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

TLDR
Electrochemotherapy is an effective treatment in the palliative management of unresectable recurrent disease with overall objective response rates of approximately 80–90%.

Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy

TLDR
A clinical study was initiated to determine if this mode of treatment would be effective against certain primary and metastatic cutaneous malignancies.

Electrochemotherapy: advantages and drawbacks in treatment of cancer patients

TLDR
Enhanced drug delivery can substantially potentiate chemotherapeutic drug effectiveness, locally at the site of the cell electroporation by electric pulses, without affecting drug effectiveness in the tissues that were not exposed to electric pulses.

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TLDR
This is the first study that documents the antitumor effects of ECT in metastatic melanoma, and may be an effective alternative to palliative surgery or irradiation in these patients.

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TLDR
ECT was shown to be an effective local treatment and was effective regardless of the histological type of the tumour, and offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate.

Electrochemotherapy: Aspects of Preclinical Development and Early Clinical Experience

TLDR
Electrochemotherapy parameters optimized in vitro are applicable in vivo and this treatment is effective in athymic nude mice for all histologic types indicating a nonimmunologic mode of action.
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