Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

@article{Mller2009ElectrochemotherapyAA,
  title={Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma},
  author={Mecker G. M{\"o}ller and Slawomir Salwa and D. Soden and Gerald C O'sullivan},
  journal={Expert Review of Anticancer Therapy},
  year={2009},
  volume={9},
  pages={1611 - 1630}
}
Treatment of recurrent or in-transit unresectable melanoma continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a therapeutic option for those patients whose lesions are not suitable for surgical resection and who have exhausted all other treatment modalities. ECT combines electroporation of tumor cells with the administration either of intravenous or intratumoral antineoplastic drugs, such as bleomycin or cisplatin. The cell membranes are thus rendered permeant to these… 

Utility of electrochemotherapy in melanoma treatment

Treatment regimens combining ECT to biological response modifiers (interleukin-2, interferon and immunotherapeutic compounds) and immunotherapy combined to ECT could broaden the therapeutic indications of ECT, by rendering it effective also on distant unreachable or untreated lesions.

Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach

Electrochemotherapy can be proposed as loco‐regional therapy for disseminated cutaneous and subcutaneous tumor lesions as alternative treatment modality to conventional therapies or as palliative care, in order to improve patients' quality of life.

Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma

Recent literature concerning electrochemotherapy and other clinical applications of electroporation for the targeted therapy of metastatic melanoma is reviewed to review recent results.

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ECT, in general, can be considered as a palliative option for cancers for which standard treatments have failed or proved to be insufficient and new technological developments are needed that will enable treatment of these tumors in daily clinical practice.

Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis

The favorable outcome obtained in the present study demonstrates that ECT is a reliable, and effective procedure that provides long-term benefit in terms of curative and palliative treatment for unresectable cutaneous lesions without adversely impacting the quality of life of patients.

Electrochemotherapy for the management of melanoma skin metastasis: a review of the literature and possible combinations with immunotherapy

Recent studies on electrochemotherapy and melanoma skin metastasis are reviewed, and the role that combinations with immunotherapy may have based on the data provided by clinical trials and translational research is commented on.

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Intralesional immunotherapy supplements systemic treatments and often achieves higher remission rates as compared to systemic therapy, particularly in loco-regional metastasis and distant soft tissue metastasis, and may act as supplement in the armament against metastatic melanoma.

omplete regression of melanoma skin etastases after electrochemotherapy plus pilimumab treatment : an unusual clinical

  • Medicine
  • 2015
A case of an advanced melanoma in which a sequential treatment with ECT plus ipilimumab achieved a complete clinical response of multiple cutaneous etastases, with unusual vitiligo-like lesions as the final utcome is described.

Electrochemotherapy in melanoma patients: a single institution experience.

The favorable outcome obtained in the present study demonstrates that ECT is a reliable, easy, fast and effective procedure showing benefits in terms of curative and palliative treatment for unresectable cutaneous lesions respecting the quality of life.

Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination

In vitro and in vivo models were preclinically developed for evaluating the efficacy and safety of ECT on different tumor cell lines and animal models to optimize dose and administration routes of drugs, duration, and intensity of the electric field.

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