Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

  title={Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma},
  author={Mecker G. M{\"o}ller and Slawomir Salwa and D. Soden and Gerald C O'sullivan},
  journal={Expert Review of Anticancer Therapy},
  pages={1611 - 1630}
Treatment of recurrent or in-transit unresectable melanoma continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a therapeutic option for those patients whose lesions are not suitable for surgical resection and who have exhausted all other treatment modalities. ECT combines electroporation of tumor cells with the administration either of intravenous or intratumoral antineoplastic drugs, such as bleomycin or cisplatin. The cell membranes are thus rendered permeant to these… 

Utility of electrochemotherapy in melanoma treatment

Treatment regimens combining ECT to biological response modifiers (interleukin-2, interferon and immunotherapeutic compounds) and immunotherapy combined to ECT could broaden the therapeutic indications of ECT, by rendering it effective also on distant unreachable or untreated lesions.

Electrochemotherapy for cutaneous and subcutaneous tumor lesions: a novel therapeutic approach

Electrochemotherapy can be proposed as loco‐regional therapy for disseminated cutaneous and subcutaneous tumor lesions as alternative treatment modality to conventional therapies or as palliative care, in order to improve patients' quality of life.

Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma

Recent literature concerning electrochemotherapy and other clinical applications of electroporation for the targeted therapy of metastatic melanoma is reviewed to review recent results.

Electrochemotherapy: An enhancement of cytotoxicity of anticancer drugs

ECT, in general, can be considered as a palliative option for cancers for which standard treatments have failed or proved to be insufficient and new technological developments are needed that will enable treatment of these tumors in daily clinical practice.

Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis

The favorable outcome obtained in the present study demonstrates that ECT is a reliable, and effective procedure that provides long-term benefit in terms of curative and palliative treatment for unresectable cutaneous lesions without adversely impacting the quality of life of patients.

Electrochemotherapy for the management of melanoma skin metastasis: a review of the literature and possible combinations with immunotherapy

Recent studies on electrochemotherapy and melanoma skin metastasis are reviewed, and the role that combinations with immunotherapy may have based on the data provided by clinical trials and translational research is commented on.

Intralesional immunotherapy as a strategy to treat melanoma

Intralesional immunotherapy supplements systemic treatments and often achieves higher remission rates as compared to systemic therapy, particularly in loco-regional metastasis and distant soft tissue metastasis, and may act as supplement in the armament against metastatic melanoma.

omplete regression of melanoma skin etastases after electrochemotherapy plus pilimumab treatment : an unusual clinical

  • Medicine
  • 2015
A case of an advanced melanoma in which a sequential treatment with ECT plus ipilimumab achieved a complete clinical response of multiple cutaneous etastases, with unusual vitiligo-like lesions as the final utcome is described.

Electrochemotherapy in melanoma patients: a single institution experience.

The favorable outcome obtained in the present study demonstrates that ECT is a reliable, easy, fast and effective procedure showing benefits in terms of curative and palliative treatment for unresectable cutaneous lesions respecting the quality of life.

Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination

In vitro and in vivo models were preclinically developed for evaluating the efficacy and safety of ECT on different tumor cell lines and animal models to optimize dose and administration routes of drugs, duration, and intensity of the electric field.



Electrochemotherapy with Intravenous Bleomycin in the Local Treatment of Skin Melanoma Metastases

ECT is a safe procedure, easily performed in terms of toxicities and cost-effectiveness ratios, and constitutes a therapeutic tool for relapsed/refractory cutaneous melanoma patients, and the repeated ECT sessions are associated with a response increase in re-treated lesions which could allow to overcome the reduced activity in >1 cm2 sized metastases.

Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors

The biological basis of electroporation therapy is outlined in this review and basic science studies and the limited clinical studies that have involved electrochemotherapy are reviewed, placed on trials involving melanoma, head and neck cancers and other primary and metastatic skin cancers.

Electrochemotherapy: An emerging cancer treatment

  • M. SadadcharamD. SodenG. O'sullivan
  • Medicine
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • 2008
Electrochemotherapy is a quick, safe, inexpensive treatment modality that has been shown to give consistently reproducible results in the treatment of solid cutaneous and subcutaneous malignant tumours and is a potential application to therapeutic modalities in the future.

Electrochemotherapy: Aspects of Preclinical Development and Early Clinical Experience

Electrochemotherapy parameters optimized in vitro are applicable in vivo and this treatment is effective in athymic nude mice for all histologic types indicating a nonimmunologic mode of action.

Therapy for unresectable recurrent and in-transit extremity melanoma.

In this patient population, intratumoral techniques have a limited role with current treatment regimens, but with the development of new drugs, these techniques may have more utility.

Electrochemotherapy with bleomycin. The first clinical experience in malignant melanoma patients

Electrochemotherapy with bleomycin offers a successful approach to the treatment of cutaneous and subcutaneous tumor lesions in patients, without side effects and with high response rate.

Treatment of cutaneous nodules using electrochemotherapy.

  • R. Heller
  • Medicine
    The Journal of the Florida Medical Association
  • 1995
A clinical trial to determine if electrochemotherapy would be effective in cutaneous and subcutaneous malignancies and two patients have responded positively to the treatment.