Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma

@article{Mller2009ElectrochemotherapyAA,
  title={Electrochemotherapy as an adjunct or alternative to other treatments for unresectable or in-transit melanoma},
  author={M. M{\"o}ller and S. Salwa and D. Soden and G. O'sullivan},
  journal={Expert Review of Anticancer Therapy},
  year={2009},
  volume={9},
  pages={1611 - 1630}
}
Treatment of recurrent or in-transit unresectable melanoma continues to be a major therapeutic challenge. Electrochemotherapy (ECT) is a therapeutic option for those patients whose lesions are not suitable for surgical resection and who have exhausted all other treatment modalities. ECT combines electroporation of tumor cells with the administration either of intravenous or intratumoral antineoplastic drugs, such as bleomycin or cisplatin. The cell membranes are thus rendered permeant to these… Expand
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ECT is a safe procedure, easily performed in terms of toxicities and cost-effectiveness ratios, and constitutes a therapeutic tool for relapsed/refractory cutaneous melanoma patients, and the repeated ECT sessions are associated with a response increase in re-treated lesions which could allow to overcome the reduced activity in >1 cm2 sized metastases. Expand
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