Electrochemistry-mass spectrometry unveils the formation of reactive triclocarban metabolites.

@article{Baumann2010ElectrochemistrymassSU,
  title={Electrochemistry-mass spectrometry unveils the formation of reactive triclocarban metabolites.},
  author={Anne Baumann and Wiebke Lohmann and Tina Rose and Ki Chang Ahn and Bruce D Hammock and Uwe Karst and Nils Helge Schebb},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 12},
  pages={2130-8}
}
Triclocarban (3,4,4'-trichlorocarbanilide, TCC) is a widely used antibacterial agent in personal care products and is frequently detected as an environmental pollutant in waste waters and surface waters. In this study, we report novel reactive metabolites potentially formed during biotransformation of TCC. The oxidative metabolism of TCC has been predicted using an electrochemical cell coupled online to liquid chromatography and electrospray ionization mass spectrometry. The electrochemical… CONTINUE READING