Electrochemiluminescent assay for detection of extremely rare mutations based on ligase reaction and bead enrichment.


The detection of rare mutations is particularly essential in many areas of biomedical research. Here, we report an ultrasensitive method to detect extremely rare point mutations based on electrochemiluminescent assay. The point mutation among large excess wild-type alleles is exclusively amplified through ligase detection reaction. The products… (More)
DOI: 10.1016/j.ab.2012.10.036


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