Electrochemical monitoring of nitric oxide released by myenteric neurons of the guinea pig ileum.

@article{Patel2008ElectrochemicalMO,
  title={Electrochemical monitoring of nitric oxide released by myenteric neurons of the guinea pig ileum.},
  author={Bhavik Anil Patel and James J Galligan and Greg M Swain and Xiaochun Bian},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2008},
  volume={20 11},
  pages={1243-50}
}
Nitric oxide (NO) released by myenteric neurons in isolated segments of guinea pig ileum was monitored in vitro using continuous amperometry. NO was detected as an oxidation current recorded with a boron-doped diamond microelectrode held at 1 V vs a Ag|AgCl reference electrode. This potential was sufficient to oxidize NO. Longitudinal muscle-myenteric plexus (LMMP) and circular muscle strip preparations were used. In the LMMP preparation, NO release was evoked by superfusion of 1 mumol L(-1… CONTINUE READING