Electrochemical monitoring of anticancer compounds on the human ovarian carcinoma cell line A2780 and its adriamycin- and Cisplatin-resistant variants.

@article{Woolley2002ElectrochemicalMO,
  title={Electrochemical monitoring of anticancer compounds on the human ovarian carcinoma cell line A2780 and its adriamycin- and Cisplatin-resistant variants.},
  author={David E. Woolley and Lynne C. Tetlow and Daman J. Adlam and D Gearey and Robert D Eden and Tim H. Ward and Terrence D. Allen},
  journal={Experimental cell research},
  year={2002},
  volume={273 1},
  pages={65-72}
}
A novel electrochemical technique which detects and monitors real-time changes in cell behavior in vitro has been used to examine the effects of recognized anticancer drugs on the human ovarian carcinoma cell line A2780 and its adriamycin (A2780adr)- and cisplatin (A2780cispt)-resistant variants. These cells, adherent to gold electrodes or sensors, modify the extracellular microenvironment at the cell:sensor interface, producing an electrochemical potential that is different from that of the… CONTINUE READING