Electrochemical molecular beacon biosensor for sequence-specific recognition of double-stranded DNA.

@article{Miao2014ElectrochemicalMB,
  title={Electrochemical molecular beacon biosensor for sequence-specific recognition of double-stranded DNA.},
  author={Xiangmin Miao and Xiaoting Guo and Zhiyou Xiao and Liansheng Ling},
  journal={Biosensors & bioelectronics},
  year={2014},
  volume={59},
  pages={
          54-7
        }
}
Direct recognition of double-stranded DNA (dsDNA) was crucial to disease diagnosis and gene therapy, because DNA in its natural state is double stranded. Here, a novel sensor for the sequence-specific recognition of dsDNA was developed based on the structure change of ferrocene (Fc) redox probe modified molecular beacon (MB). For constructing such a sensor, gold nanoparticles (AuNPs) were initially electrochemical-deposited onto glass carbon electrode (GCE) surface to immobilize thiolated MB in… CONTINUE READING
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