Electrochemical impedance immunosensor based on gold nanoparticles-protein G for the detection of cancer marker epidermal growth factor receptor in human plasma and brain tissue.

@article{Elshafey2013ElectrochemicalII,
  title={Electrochemical impedance immunosensor based on gold nanoparticles-protein G for the detection of cancer marker epidermal growth factor receptor in human plasma and brain tissue.},
  author={Reda Elshafey and Ana Carolina Giudice Tavares and Mohamed Siaj and Mohammed Zourob},
  journal={Biosensors & bioelectronics},
  year={2013},
  volume={50},
  pages={143-9}
}
A sensitive label-free impedimetric immunosensor for the detection of cancer biomarker epidermal growth factor receptor (EGFR) was developed with a limit of detection as low as 0.34 pg mL(-1) in PBS and 0.88 pg mL(-1) in human plasma. The gold nanoparticles were electrodeposited to modify the gold surface and to increase the electrochemical active area by a factor of approximately 3, i.e. by 68%. Protein G was used as scaffold for well oriented EGFR antibodies immobilization. Under optimal… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-3 of 3 references

Biochemical and Biophysical Research

  • Chen, J-C, S. Sadhasivam, Lin, F-H
  • Process Biochemistry
  • 2011
Highly Influential
6 Excerpts

The Oncologist

  • C. L. Arteaga
  • Sensors and Actuators B
  • 2002
Highly Influential
3 Excerpts

Biosensors and Bioelectronics

  • P. U. Arumugam
  • 2012

Similar Papers

Loading similar papers…