Electrochemical immunosensor using p-aminophenol redox cycling by hydrazine combined with a low background current.

@article{Das2007ElectrochemicalIU,
  title={Electrochemical immunosensor using p-aminophenol redox cycling by hydrazine combined with a low background current.},
  author={Jagotamoy Das and Kyungmin Jo and Jae Wook Lee and Haesik Yang},
  journal={Analytical chemistry},
  year={2007},
  volume={79 7},
  pages={
          2790-6
        }
}
Signal amplification and noise reduction are crucial for obtaining low detection limits in biosensors. Here, we present an electrochemical immunosensor in which the signal amplification is achieved using p-aminophenol (AP) redox cycling by hydrazine, and the noise level is reduced by implementing a low background current. The redox cycling is obtained in a simple one-electrode, one-enzyme format. In a sandwich-type heterogeneous immunosensor for mouse IgG, an alkaline phosphatase label converts… CONTINUE READING
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