Electrochemical aptasensor of human cellular prion based on multiwalled carbon nanotubes modified with dendrimers: a platform for connecting redox markers and aptamers.

@article{Miodek2013ElectrochemicalAO,
  title={Electrochemical aptasensor of human cellular prion based on multiwalled carbon nanotubes modified with dendrimers: a platform for connecting redox markers and aptamers.},
  author={Anna Miodek and Gabriela Castillo and Tibor Hianik and Hafsa Korri-Youssoufi},
  journal={Analytical chemistry},
  year={2013},
  volume={85 16},
  pages={7704-12}
}
The present work aims to develop an electrochemical biosensor based on aptamer able to detect human cellular prions PrP(C) as a model biomarker of prion disease with high sensitivity. We designed the biosensor using multiwalled carbon nanotubes (MWCNTs) modified with polyamidoamine dendrimers of fourth generation (PAMAM G4) which in turn were coupled to DNA aptamers used as bioreceptors. Electrochemical signal was detected by a ferrocenyl redox marker incorporated between the dendrimers and… CONTINUE READING
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