Electrochemical aptasensor for human osteopontin detection using a DNA aptamer selected by SELEX.

Abstract

A DNA aptamer with affinity and specificity for human osteopontin (OPN), a potential breast cancer biomarker, was selected using the SELEX process, considering its homology rate and the stability of its secondary structures. This aptamer exhibited a satisfactory affinity towards OPN, showing dissociation constants lower than 2.5 nM. It was further used to… (More)
DOI: 10.1016/j.aca.2017.07.071

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