Electrochemical and quartz crystal microbalance detection of the cholera toxin employing horseradish peroxidase and GM1-functionalized liposomes.

@article{Alfonta2001ElectrochemicalAQ,
  title={Electrochemical and quartz crystal microbalance detection of the cholera toxin employing horseradish peroxidase and GM1-functionalized liposomes.},
  author={Lital Alfonta and Itamar Willner and Daniel J. Throckmorton and Anup Singh},
  journal={Analytical chemistry},
  year={2001},
  volume={73 21},
  pages={5287-95}
}
An ultrasensitive method for the detection of the cholera toxin (CT) using electrochemical or microgravimetric quartz crystal microbalance transduction means is described. Horseradish peroxidase (HRP) and GM1-functionalized liposomes act as catalytic recognition labels for the amplified detection of the cholera toxin based on highly specific recognition of CT by the ganglioside GM1. The sensing interface consists of monoclonal antibody against the B subunit of CT that is linked to protein G… CONTINUE READING

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