Electrocardiography and repolarization abnormalities in cardiac safety: Benefits and limitations of fully automated methods for QT measurement

@article{Kligfield2010ElectrocardiographyAR,
  title={Electrocardiography and repolarization abnormalities in cardiac safety: Benefits and limitations of fully automated methods for QT measurement},
  author={Paul D. Kligfield},
  journal={2010 Computing in Cardiology},
  year={2010},
  pages={253-256}
}
During early phase drug safety trials in humans, prolongation of the rate-corrected QT interval has become a surrogate marker for heterogeneity of ventricular repolarization that can cause potentially fatal arrhythmic events. “Thorough QT” studies have been designed to test for clinically significant QT prolongation by new drugs, with “positive controls” used to assess sensitivity of the method Measurement of the QT interval may be done manually, automatically, or by adjudication of selected… CONTINUE READING