Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study.

STUDY OBJECTIVE To determine the electrocardiographic effects of coadministration of lofexidine and methadone. DESIGN Prospective, double-blind study. SETTING Outpatient drug treatment research clinic. PARTICIPANTS Fourteen adults (mean +/- SD age 34.9 +/- 5.3 yrs) with physical dependence on opioids. INTERVENTION Participants were stabilized on… (More)