Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs.

@article{Xin2011ElectrocardiographicAB,
  title={Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs.},
  author={Yanfei Xin and Sheng Zhang and Liqiang Gu and Shupeng Liu and Haiyan Gao and Zhenqiang You and Guoliang Zhou and Lei Wen and Jian Yu and Yaoxian Xuan},
  journal={Biological & pharmaceutical bulletin},
  year={2011},
  volume={34 10},
  pages={1523-6}
}
Doxorubicin (DOX) is a potent antitumor agent, but the cardiotoxicity mediated by the formation of reactive oxygen species limit its clinical use. The present study aims to explore electrocardiographic and biochemical evidence for the cardioprotective effect of two antioxidants, Lycium barbarum polysaccharides (LBP, the main antioxidant in Lycium barbarum) and edaravone (a potent free radical scavenger, EDA) against DOX-induced acute cardiotoxicity in beagle dogs. In this study, male beagle… CONTINUE READING
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