Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block.

@article{Mazel1999ElectrocardiographicAI,
  title={Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block.},
  author={J. Mazel and N. El-Sherif and J. Buyon and M. Boutjdir},
  journal={Circulation},
  year={1999},
  volume={99 14},
  pages={
          1914-8
        }
}
  • J. Mazel, N. El-Sherif, +1 author M. Boutjdir
  • Published 1999
  • Medicine
  • Circulation
  • BACKGROUND It is a widely held view that congenital heart block (CHB) is caused by the transplacental transfer of maternal autoantibodies (anti-SSA/Ro and/or anti-SSB/La) into the fetal circulation. To test this hypothesis and to reproduce human CHB, an experimental mouse model (BALB/c) was developed by passive transfer of human autoantibodies into pregnant mice. METHODS AND RESULTS Timed pregnant mice (n=54) were injected with a single intravenous bolus of purified IgG containing human anti… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES
    Neonatal lupus syndromes.
    • 246