Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block.

@article{Mazel1999ElectrocardiographicAI,
  title={Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block.},
  author={J A Mazel and Nabil El-Sherif and Jill P. Buyon and Mohamed Boutjdir},
  journal={Circulation},
  year={1999},
  volume={99 14},
  pages={1914-8}
}
BACKGROUND It is a widely held view that congenital heart block (CHB) is caused by the transplacental transfer of maternal autoantibodies (anti-SSA/Ro and/or anti-SSB/La) into the fetal circulation. To test this hypothesis and to reproduce human CHB, an experimental mouse model (BALB/c) was developed by passive transfer of human autoantibodies into pregnant mice. METHODS AND RESULTS Timed pregnant mice (n=54) were injected with a single intravenous bolus of purified IgG containing human anti… CONTINUE READING