Electroanalysis of amino acid substitutions in bioengineered acetylcholinesterase.

Abstract

This study reports the electrochemical profiling of Nippostrongylus brasiliensis acetylcholinesterase (AChE) wild-type and mutant proteins. An irreversible oxidation signal of electro-active tyrosine (Y), tryptophan (W) and cysteine (C) residues in five mutant proteins along with the wild-type AChE were detected using square-wave voltammetry (SWV) on screen… (More)
DOI: 10.1016/j.bioelechem.2012.07.004

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