Electroacupuncture treatment of morphine-dependent mice reduces signs of withdrawal, without showing cross-tolerance.

Abstract

Morphine pellets (75 mg morphine base per pellet) were implanted subcutaneously in mice (B6AF1/J) and were surgically removed after 3 or 8 days. During morphine abstinence (7 h after pellet removal), the mice were treated with electroacupuncture (EA). The results indicate that EA analgesia shows no cross-tolerance to morphine. Additionally, EA reduced… (More)

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Cite this paper

@article{Cheng1980ElectroacupunctureTO, title={Electroacupuncture treatment of morphine-dependent mice reduces signs of withdrawal, without showing cross-tolerance.}, author={R. S. Cheng and Bruce A Pomeranz and G. Yu}, journal={European journal of pharmacology}, year={1980}, volume={68 4}, pages={477-81} }