Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein

@article{Kim2003ElectrogeneTO,
  title={Electro-gene therapy of collagen-induced arthritis by using an expression plasmid for the soluble p75 tumor necrosis factor receptor-Fc fusion protein},
  author={J Kim and S Ho and Woong Hahn and J-G Jeong and E-J Park and Hyun-Joo Lee and Seung Shin Yu and C-S Lee and Y-W Lee and S W Kim},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={1216-1224}
}
Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis, and antagonism of TNF may reduce the activity of the disease. Among a number of techniques for gene transfer in vivo, the direct injection of plasmid DNA into muscle is simple, inexpensive, and safe. In this study, we attempted to treat collagen-induced arthritis (CIA) with anti-TNF gene therapy by transferring the plasmid encoding soluble p75 TNF receptor linked to the Fc portion of… CONTINUE READING