Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibers and partial functional recovery after spinal cord injury.

@article{Yan2011ElectroacupuncturePD,
  title={Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibers and partial functional recovery after spinal cord injury.},
  author={Qing Yan and Jingwen Ruan and Ying Ding and Wen-jie Li and Yan Li and Yuan-Shan Zeng},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2011},
  volume={63 1-2},
  pages={
          151-6
        }
}
  • Qing Yan, Jingwen Ruan, Yuan-Shan Zeng
  • Published 2011
  • Biology, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
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metrc.smu.edu.cn:81
68 Citations
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...

References

SHOWING 1-10 OF 26 REFERENCES

Electro-acupuncture improves survival and migration of transplanted neural stem cells in injured spinal cord in rats.

TLDR
The results suggest that the combination of EA and NSCs improves the survival and migration of N SCs in injured spinal cord in rats.

Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injury

TLDR
Results demonstrate that cografted NT-3-SCs and NSCs is a potential therapy for SCI and could promote partly structural and functional recovery of the SCI rats.

A STUDY ON THE COMBINATION OF GOREMOR VESSEL ELECTROACUPUNCTURE AND TRANSPLANTED NEURAL STEM CELLS TO PROMOTE THE SURVIVAL ANDA XONAL REGENERATION OF INJURED NEURONS IN COMPLETELY TRANSECTED SPINAL CORD IN RATS

TLDR
The combination of Goremor vessel electroacupuncture and transplanted NSCs may promote the survival and axonal regeneration of injured neurons in completely transected spinal cord of rats.

Transplants of Human Mesenchymal Stem Cells Improve Functional Recovery After Spinal Cord Injury in the Rat

TLDR
The findings indicate that hMSCs may facilitate recovery from spinal cord injury by remyelinating spared white matter tracts and/or by enhancing axonal growth.

Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation

TLDR
The data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury, and indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals.

Neurotrophins and Neuroprotection Improve Axonal Regeneration into Schwann Cell Transplants Placed in Transected Adult Rat Spinal Cord

Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery

TLDR
Marrow stromal cells constitute an easily accessible, easily expandable source of cells that may prove useful in the establishment of spinal cord repair protocols and possibly effects on functional outcome in animals rendered paraplegic.

Effect of Electroacupuncture on Neurotrophin Expression in Cat Spinal Cord after Partial Dorsal Rhizotomy

TLDR
It is demonstrated that EA can increase the expression of endogenous NGF at both the mRNA and protein level, and BDNF and NT-3 at the protein level and it is postulated that EA may promote the plasticity of the spinal cord by inducing increased expression of neurotrophins.

EFFECTS OF DU MERIDIAN ELECTROACUPUNCTURE AND TRANSPLANTED NEURAL STEM CELLS ON THE FUNCTIONAL RECOVERY OF THE HIND LIMBS IN SPINAL CORD TRANSECTED RATS

TLDR
Combination of DU Meridian electroacupuncture and transplanted NSCs may promote the functional recovery of the hind limb locomotion in rat spinal cord transected completely.

Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation.

TLDR
It is shown that a population of neuronal cells can be specifically generated from MSCs and that induced cells may allow for a neuroreconstructive approach.