Electrically controlled rapid release of actives encapsulated in double-emulsion droplets.

@article{Jia2018ElectricallyCR,
  title={Electrically controlled rapid release of actives encapsulated in double-emulsion droplets.},
  author={Yankai Jia and Yukun Ren and Likai Hou and Weiyu Liu and Tianyi Jiang and Xiaokang Deng and Ye Tao and Hongyuan Jiang},
  journal={Lab on a chip},
  year={2018},
  volume={18 7},
  pages={
          1121-1129
        }
}
Controlled release of multiple actives after encapsulation in a microenvironment is significant for various biological and chemical applications such as controlled drug delivery and transplantation of encapsulated cells. However, traditional systems often lack efficient encapsulation and release of multiple actives, especially when incorporated substances must be released at a targeted location. Here, we present a straightforward approach to release multiple actives at a prescribed position in… 

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References

SHOWING 1-10 OF 43 REFERENCES

Biodegradable core-shell carriers for simultaneous encapsulation of synergistic actives.

A novel biodegradable core-shell carrier system fabricated in a one-step, solvent-free process on a microfluidic chip that demonstrates the efficacy through the simultaneous encapsulation and controlled release of two synergistic anticancer drugs using two cancer-derived cell lines.

Microfluidic Production of Biodegradable Microcapsules for Sustained Release of Hydrophilic Actives.

Biodegradable microcapsules with a large aqueous lumen and ultrathin membrane are microfluidically designed for sustained release of hydrophilic bioactives using water-in-oil- in-water double-emulsion drops as a template, believed to be promising for the in vivo sustainedrelease of drugs for high and long-term efficacy.

Continuously Electrotriggered Core Coalescence of Double-Emulsion Drops for Microreactions.

The presented method can be readily used for the controlled triggering of microreactions with high flexibility for a wide range of applications, especially for continuous chemical or cell assays.

Polymer microcapsules with programmable active release.

Tuning the degree of membrane fluidity by tailoring the amount of plasticizing stimulus present allows us to obtain temporal variation of the release kinetics from a subsecond abrupt burst release to a slow sustained release of encapsulant over many minutes.

Sequential Coalescence Enabled Two-Step Microreactions in Triple-Core Double-Emulsion Droplets Triggered by an Electric Field.

A microfluidic approach is reported for the conduction of two-step microreactions by electrically fusing three cores inside double-emulsion droplets and this technique should benefit a wide range of applications that require multistep reactions in micrometer scale.

A dual-core double emulsion platform for osmolarity-controlled microreactor triggered by coalescence of encapsulated droplets.

A glass capillary microfluidic approach to first fabricate osmolarity-responsive Water-in-Oil- in-Water (W/O/W) double emulsion containing two different inner droplets/cores and to trigger the coalescence between the encapsulated droplets precisely, establishes a novel microreactor for nanoliter-scale reactions.

Microfluidic melt emulsification for encapsulation and release of actives.

A microfluidic melt emulsification method for encapsulation and release of actives and the same concept is demonstrated to encapsulate multiple actives in multicompartment capsules, which are promising as multifunctional capsules and microreactors.

Double-emulsion drops with ultra-thin shells for capsule templates.

An emulsification technique is introduced that creates monodisperse double-emulsion drops with a core-shell geometry having an ultra-thin wall as a middle layer, potentially useful for encapsulation and delivery of drugs, cosmetics, and nutrients.

Microfluidic-assisted fabrication of carriers for controlled drug delivery.

An overview of different fluidic principles used in the literature to produce either polymeric microparticles or nanoparticles, focusing on the materials that could have an impact on drug delivery.