Electrical stimulation of the pedunculopontine tegmental nucleus in freely moving awake rats: time- and site-specific effects on two-way active avoidance conditioning.

@article{Andero2007ElectricalSO,
  title={Electrical stimulation of the pedunculopontine tegmental nucleus in freely moving awake rats: time- and site-specific effects on two-way active avoidance conditioning.},
  author={Ra{\"u}l Andero and Meritxell Torras-Garc{\'i}a and Mar{\'i}a Fernanda Quiroz-Padilla and David Costa-Miserachs and Margalida Coll-Andreu},
  journal={Neurobiology of learning and memory},
  year={2007},
  volume={87 4},
  pages={510-21}
}
The pedunculopontine tegmental nucleus (PPTg) is involved in the regulation of thalamocortical transmission and of several functions related to ventral and dorsal striatal circuits. Stimulation of the PPTg in anesthetized animals increases cortical arousal, cortical acetylcholine release, bursting activity of mesopontine dopaminergic cells, and striatal dopamine release. It was hypothetized that PPTg stimulation could improve learning by enhancing cortical arousal and optimizing the activity of… CONTINUE READING