Electrical stimulation of nucleus raphe dorsalis changes morphine self-administration and withdrawal symptoms in rats.

@article{Alaei2002ElectricalSO,
  title={Electrical stimulation of nucleus raphe dorsalis changes morphine self-administration and withdrawal symptoms in rats.},
  author={Hojatolah Alaei and Ali Asghar Pourshanazari and Ali Hoseinpoor Rafati},
  journal={Pathophysiology : the official journal of the International Society for Pathophysiology},
  year={2002},
  volume={9 1},
  pages={
          1
        }
}
The involvement of antero-dorsal part of the nucleus raphe dorsalis (NRD) in motivational aspects of drug-taking behaviour during initiation of drug self-administration was investigated using a recently developed behavioural paradigm. In separate experiments animals were allowed to self-administer morphine (1 mg/kg per inf) ten consecutive daily 3-h sessions. During all morphine self-administration sessions lever-press behaviour was measured in absence of electrical stimulation of NRD, as an… CONTINUE READING