Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation.

@article{Xia1997ElectricalSO,
  title={Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation.},
  author={Ying Xia and Luis Maximilian Buja and Richard C. Scarpulla and Jeanie B. McMillin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 21},
  pages={11399-404}
}
Electrical stimulation of neonatal cardiac myocytes produces hypertrophy and cellular maturation with increased mitochondrial content and activity. To investigate the patterns of gene expression associated with these processes, cardiac myocytes were stimulated for varying times up to 72 hr in serum-free culture. The mRNA contents for genes associated with transcriptional activation [c-fos, c-jun, JunB, nuclear respiratory factor 1 (NRF-1)], mitochondrial proliferation [cytochrome c (Cyt c… CONTINUE READING

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