Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.

@article{Milad2004ElectricalSO,
  title={Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.},
  author={Mohammed R. Milad and Ivan Vidal-Gonzalez and Gregory J Quirk},
  journal={Behavioral neuroscience},
  year={2004},
  volume={118 2},
  pages={389-94}
}
The authors recently showed that extinction of auditory fear conditioning leads to potentiation of tone-evoked activity of neurons in the infralimbic (IL) subregion of the medial prefrontal cortex, suggesting that IL inhibits fear after extinction (M. R. Milad, & G. J. Quirk, 2002). In support of this finding, pairing conditioned tones with brief (300-ms) electrical stimulation of IL reduces conditioned freezing. The present study showed that IL stimulation inhibits freezing if given 0.1 s… CONTINUE READING

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