Electrical stimulation of a small brain area reversibly disrupts consciousness

@article{Koubeissi2014ElectricalSO,
  title={Electrical stimulation of a small brain area reversibly disrupts consciousness},
  author={Mohamad Z Koubeissi and Fabrice Bartolomei and Abdelrahman Beltagy and Fabienne Picard},
  journal={Epilepsy \& Behavior},
  year={2014},
  volume={37},
  pages={32-35}
}
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References

SHOWING 1-10 OF 18 REFERENCES
Electrical Stimulation of the Human Brain: Perceptual and Behavioral Phenomena Reported in the Old and New Literature
TLDR
This comprehensive review contains a detailed summary of the data obtained from electrical brain stimulation in humans in the last 100 years, suggesting that the modulation of activity within a localized, but distributed, neuroanatomical network might explain the perceptual and behavioral phenomena that are reported during focal electrical stimulation of the human brain.
Impaired consciousness during temporal lobe seizures is related to increased long-distance cortical-subcortical synchronization.
TLDR
It is suggested that excessive synchronization overloads the structures involved in consciousness processing, preventing them from treating incoming information, thus resulting in LOC.
The Global Workspace (GW) Theory of Consciousness and Epilepsy
TLDR
It is suggested that excessive synchrony could prevent this distributed network to reach the minimal level of differentiation and complexity necessary to the coding of conscious representations, and specifies the physiological window of neural coherence associated with conscious processing.
Converging PET and fMRI evidence for a common area involved in human focal epilepsies
TLDR
The findings of cerebral blood flow and GABAergic changes, irrespective of where interictal or ictal activity occurs in the cortex, suggest that this area of the human primary olfactory cortex may be an attractive new target for epilepsy therapy, including neurosurgery, electrical stimulation, and focal drug delivery.
Consciousness supporting networks
The Neural Correlates of Consciousness
  • G. Tononi, C. Koch
  • Psychology, Medicine
    Annals of the New York Academy of Sciences
  • 2008
TLDR
This review examines recent advances in the study of brain correlates of consciousness and discusses dynamic aspects of neural activity, such as sustained versus phasic activity, feedforward versus reentrant activity, and the role of neural synchronization.
Impaired consciousness in epilepsy
Pre-ictal synchronicity in limbic networks of mesial temporal lobe epilepsy
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