Electrical stimulation of a small brain area reversibly disrupts consciousness

  title={Electrical stimulation of a small brain area reversibly disrupts consciousness},
  author={Mohamad Z Koubeissi and Fabrice Bartolomei and Abdelrahman Beltagy and Fabienne Picard},
  journal={Epilepsy \& Behavior},
Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response
The authors conclude that the right dorsal anterior insula cortex (dAIC) is a potential cortical gate responsible for LOBR, and finds that the dAIC had reduced functional connectivity with the frontoparietal regions, specifically the dorsolateral prefrontal cortex and inferior parietal lobule, after LOBr.
The Claustrum in Relation to Seizures and Electrical Stimulation
It is found that HFS of the claustrum decreased the performance in the operant task in a manner that was proportional to the current intensity used, and CCEPs established the presence of effective connectivity between both claustra and bilateral hippocampi indicating that these connections may be part of the circuitry involved in alteration of consciousness in limbic seizures.
Electrical Stimulation in the Claustrum Area Induces a Deepening of Isoflurane Anesthesia in Rat
It is shown that electrical stimulation of the claustrum area during slow-wave isoflurane anesthesia induces a transitory increase in anesthetic depth, documented by the appearance of a BS ECoG pattern, and suggests a potential role of claustrums in anesthesia.
Imaging the effective networks associated with cortical function through intracranial high-frequency stimulation.
By performing a frequency-domain analysis of the EEG responses during DES, a new intracranial stimulation paradigm and signal analysis methodology allowing to disambiguate EEG responses from stimulation artifacts is introduced, highlighting the spatial extent of the networks associated with clinical effects.
Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study
High‐frequency stimulation in the cingulate cortex elicits body perception changes, associated with a decreased connectivity of the dominant posterior insula and increased coupling between other structures, located particularly in the nondominant hemisphere.
On the relation between complex brain activity and consciousness
Why does it feel like something to be awake? I.e. how is consciousness generated by the body, the brain in particular? Seeking to map phenomenological properties of any first person experience to
Neuromodulation of consciousness disorders
The purpose of this chapter is to critically analyze the progress of these therapeutic methods and to review what is still needed to improve the impaired conscious states.
Is Consciousness Dissectible? Acute Slice Electrophysiology and a Bayesian Interpretation of Neural Correlates of Consciousness
The acute brain slicing method has become one of the foundations of modern neuroscience research. It is a laboratory technique in electrophysiology, which allows the study of electrical properties
Modulation of Cortical Oscillations by Low-Frequency Direct Cortical Stimulation Is State-Dependent
It is demonstrated with a static model and a neural oscillator model that recurrent excitation in the thalamo- cortical circuit, together with recruitment of cortico-cortical connections, can explain the enhancement of oscillations by brain stimulation as a function of brain state.


Electrical Stimulation of the Human Brain: Perceptual and Behavioral Phenomena Reported in the Old and New Literature
This comprehensive review contains a detailed summary of the data obtained from electrical brain stimulation in humans in the last 100 years, suggesting that the modulation of activity within a localized, but distributed, neuroanatomical network might explain the perceptual and behavioral phenomena that are reported during focal electrical stimulation of the human brain.
Impaired consciousness during temporal lobe seizures is related to increased long-distance cortical-subcortical synchronization.
It is suggested that excessive synchronization overloads the structures involved in consciousness processing, preventing them from treating incoming information, thus resulting in LOC.
The Global Workspace (GW) Theory of Consciousness and Epilepsy
It is suggested that excessive synchrony could prevent this distributed network to reach the minimal level of differentiation and complexity necessary to the coding of conscious representations, and specifies the physiological window of neural coherence associated with conscious processing.
Converging PET and fMRI evidence for a common area involved in human focal epilepsies
The findings of cerebral blood flow and GABAergic changes, irrespective of where interictal or ictal activity occurs in the cortex, suggest that this area of the human primary olfactory cortex may be an attractive new target for epilepsy therapy, including neurosurgery, electrical stimulation, and focal drug delivery.
Consciousness supporting networks
The Neural Correlates of Consciousness
  • G. Tononi, C. Koch
  • Psychology, Medicine
    Annals of the New York Academy of Sciences
  • 2008
This review examines recent advances in the study of brain correlates of consciousness and discusses dynamic aspects of neural activity, such as sustained versus phasic activity, feedforward versus reentrant activity, and the role of neural synchronization.
Impaired consciousness in epilepsy
Pre-ictal synchronicity in limbic networks of mesial temporal lobe epilepsy