Electrical stimulation modulates fate determination of differentiating embryonic stem cells.

@article{Yamada2007ElectricalSM,
  title={Electrical stimulation modulates fate determination of differentiating embryonic stem cells.},
  author={Masahisa Yamada and Kentaro Tanemura and Seiji Okada and Akio Iwanami and Masaya Nakamura and Hideaki Mizuno and Michiru Ozawa and Ritsuko Ohyama-Goto and Naohito Kitamura and Masako Kawano and Kyoko Tan-Takeuchi and Chiho Ohtsuka and Atsushi Miyawaki and Akihiko Takashima and Masaharu Ogawa and Yoshiaki Toyama and Hideyuki Okano and Takashi Kondo},
  journal={Stem cells},
  year={2007},
  volume={25 3},
  pages={562-70}
}
A clear understanding of cell fate regulation during differentiation is key in successfully using stem cells for therapeutic applications. Here, we report that mild electrical stimulation strongly influences embryonic stem cells to assume a neuronal fate. Although the resulting neuronal cells showed no sign of specific terminal differentiation in culture, they showed potential to differentiate into various types of neurons in vivo, and, in adult mice, contributed to the injured spinal cord as… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Thromb Haemost

  • Thromb Haemost
  • 2008

Design and conduct of clinical trials: Report of the Clinical Trials Subcommittee of the International Dry Eye WorkShop Ocul Surf

  • K Tsubota, P Asbell, +5 authors H Watanabe
  • Design and conduct of clinical trials: Report of…
  • 2007

Similar Papers

Loading similar papers…