Electrical stimulation induces the level of TGF-beta1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway.

@article{Zhuang1997ElectricalSI,
  title={Electrical stimulation induces the level of TGF-beta1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway.},
  author={Hongming Zhuang and Wei Wang and Richard M Seldes and A David Tahernia and Huapeng Fan and Carl T. Brighton},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={237 2},
  pages={225-9}
}
It is well-known that electrical stimulation can prompt healing of bone fractures. However, the mechanism involved is less clear. In this study, we found that capacitively coupled electric field-induced proliferation of osteoblastic cells (MC3T3-E1) accompanied increased levels of transforming growth factor-beta 1 (TGF-beta1) mRNA determined by quantitative reverse transcription/polymerase chain reaction. Previous reports have shown that verapamil and W-7, both of which block voltage gated… CONTINUE READING

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